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KMID : 1024420110150010064
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Food Engineering Progress
2011 Volume.15 No. 1 p.64 ~ p.69
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Effects on Hot Water Extract of Schizandra chinensis on Colon Cancer Cell Line
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Ryu Min-Ju
Chung Ha-Sook
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Abstract
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The anticancer activity of Schizandra chinensis Baillon was investigated for the development of functional food resources. The antiproliferative activity of hot water extracts of Schizandra chinensis Baillon in human colon cancer cell line (HT-29) were identified using cell viability, morphology study, cell cycle and RT-PCR analyses. HT-29 cells were cultured in several concentrations (0, 1.0, 2.0, 4.0 mg/mL) of water extracts of Schizandra chinensis Baillon. In our study, colon cancer cell growth could be inhibited by hot water extracts of Schizandra chinensis Baillon in a dose-dependent manners. It was associated with morphological changes and apoptotic cell death with cell shrinking, chromatin condensation, apoptotic bodies and cell cycle analysis. These results suggest that Schizandra chinensis Baillon may inhibit the growth of human colon cancer cells by various apoptosis-aiding activities as well as apoptosis itself.
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KEYWORD
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Schizandra chinensis Baillon. hot water extraction, freeze drying, colon cancer, apoptosis
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